DNA Methylation Profiles of Ovarian Clear Cell Carcinoma

• Published in: Cancer epidemiology, biomarkers & prevention Vol. 31; no. 1; pp. 132 - 141
• Main Authors: Cunningham, Julie M, Winham, Stacey J, Wang, Chen, Weiglt, Britta, Fu, Zhuxuan, Armasu, Sebastian M, McCauley, Bryan M, Brand, Alison H, Chiew, Yoke-Eng, Elishaev, Esther, Gourley, Charlie, Kennedy, Catherine J, Laslavic, Angela, Lester, Jenny, Piskorz, Anna, Sekowska, Magdalena, Brenton, James D, Churchman, Michael, DeFazio, Anna, Drapkin, Ronny, Elias, Kevin M, Huntsman, David G, Karlan, Beth Y, Köbel, Martin, Konner, Jason, Lawrenson, Kate, Papaemmanuil, Elli, Bolton, Kelly L, Modugno, Francesmary, Goode, Ellen L
• Format: Journal Article
• Language: English
• Published: United States 01.01.2022
• Subjects: Adenocarcinoma, Clear Cell - ethnology; Adenocarcinoma, Clear Cell - genetics; Adenocarcinoma, Clear Cell - pathology; Adult; Aged; Aged, 80 and over; Aneuploidy; Class I Phosphatidylinositol 3-Kinases - genetics; CpG Islands - genetics; Disease Progression; DNA Methylation; DNA-Binding Proteins - genetics; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Middle Aged; Mutation; Neoplasm Staging; Ovarian Neoplasms - ethnology; Ovarian Neoplasms - genetics; Ovarian Neoplasms - pathology; Prognosis; Transcription Factors - genetics; Tumor Suppressor Protein p53 - genetics

Ovarian clear cell carcinoma (OCCC) is a rare ovarian cancer histotype that tends to be resistant to standard platinum-based chemotherapeutics. We sought to better understand the role of DNA methylation in clinical and biological subclassification of OCCC. We interrogated genome-wide methylation usi...