Integrated proteomics and metabolomics analysis of D-pinitol function during hippocampal damage in streptozocin-induced aging-accelerated mice

• Published in: Frontiers in molecular neuroscience Vol. 16; p. 1251513
• Main Authors: Li, Xiaoxia, Gao, Yuan, Li, Baoying, Zhao, Wenqian, Cai, Qian, Yin, Wenbin, Zeng, Shudong, Li, Xiaoli, Gao, Haiqing, Cheng, Mei
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 30.10.2023
• Subjects: D-pinitol; diabetes; hippocampal damage; metabolomics; proteomics

Diabetes can cause hippocampal damage and lead to cognitive impairment. Diabetic cognitive impairment (DCI) is a chronic complication of diabetes associated with a high disability rate; however, its pathogenesis and therapeutic targets are unclear. We aimed to explore the mechanism of hippocampal da...