A noninvasive estimation of cerebral perfusion pressure using critical closing pressure

• Published in: Journal of neurosurgery Vol. 123; no. 3; p. 638
• Main Authors: Varsos, Georgios V, Kolias, Angelos G, Smielewski, Peter, Brady, Ken M, Varsos, Vassilis G, Hutchinson, Peter J, Pickard, John D, Czosnyka, Marek
• Format: Journal Article
• Language: English
• Published: United States 01.09.2015
• Subjects: Adolescent; Adult; Blood Flow Velocity - physiology; Blood Pressure - physiology; Cerebrovascular Circulation - physiology; Craniocerebral Trauma - diagnostic imaging; Craniocerebral Trauma - physiopathology; Female; Humans; Intracranial Pressure - physiology; Male; Middle Aged; Monitoring, Physiologic; Retrospective Studies; Sensitivity and Specificity; Ultrasonography, Doppler, Transcranial; Young Adult; IQR = interquartile range; TBI = traumatic brain injury; AUC = area under the curve; TAU = time constant of the cerebrovascular arterial bed; ABP = arterial blood pressure; CVR = cerebrovascular resistance; CPP = cerebral perfusion pressure; MCA = middle cerebral artery; eCPP = noninvasive estimator of CPP; ICP = intracranial pressure; vascular disorders; transcranial Doppler ultrasonography; GOS = Glasgow Outcome Scale; critical closing pressure; CBF = cerebral blood flow; FV = flow velocity; GCS = Glasgow Coma Scale; TCD = transcranial Doppler; ROC = receiver operating characteristic; noninvasive model; CrCP = critical closing pressure; cerebral perfusion pressure; nICP = noninvasive estimator of ICP

Cerebral blood flow is associated with cerebral perfusion pressure (CPP), which is clinically monitored through arterial blood pressure (ABP) and invasive measurements of intracranial pressure (ICP). Based on critical closing pressure (CrCP), the authors introduce a novel method for a noninvasive es...