Human NK Cell Cytoskeletal Dynamics and Cytotoxicity Are Regulated by LIM Kinase

• Published in: The Journal of immunology (1950) Vol. 205; no. 3; pp. 801 - 810
• Main Authors: Duvall, Melody G, Fuhlbrigge, Mary E, Reilly, Roisin B, Walker, Katherine H, Kılıç, Ayşe, Levy, Bruce D
• Format: Journal Article
• Language: English
• Published: United States 01.08.2020
• Subjects: Cytoskeleton - immunology; Dexamethasone - pharmacology; Humans; Killer Cells, Natural - immunology; Lim Kinases - immunology; Lipoxins - antagonists & inhibitors; Lipoxins - immunology

NK cells provide immune surveillance and host protection against viruses and tumors through their cytotoxic effector function. Cytoskeletal rearrangement is necessary for NK cell lytic granule trafficking and immune synapse formation to trigger apoptosis of targeted cells. LIM kinase (LIMK) regulate...