A Feasibility Study of the Intraductal Administration of Chemotherapy

• Published in: Cancer prevention research (Philadelphia, Pa.) Vol. 6; no. 1; pp. 51 - 58
• Main Authors: Love, Susan M., Zhang, Wei, Gordon, Eva J., Rao, Jianyu, Yang, Hongying, Li, Junyao, Zhang, Bailin, Wang, Xiang, Chen, Guoji, Zhang, Baoning
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 01.01.2013
• Subjects: Adult; Aged; Animals; Antineoplastic Agents - administration & dosage; Biological and medical sciences; Breast - pathology; Breast Neoplasms - drug therapy; Carboplatin - administration & dosage; Carboplatin - pharmacokinetics; China; DNA - metabolism; Dose-Response Relationship, Drug; Doxorubicin - administration & dosage; Doxorubicin - pharmacokinetics; Drug Delivery Systems; Feasibility Studies; Female; Humans; Inflammation; Intercalating Agents - pharmacology; Medical sciences; Middle Aged; Miscellaneous; Neoplasm Invasiveness; Nipples - pathology; Prevention and actions; Public health. Hygiene; Public health. Hygiene-occupational medicine; Time Factors; China; Chemotherapy; Feasibility; Treatment

Preclinical data have shown the potential of the intraductal administration of chemotherapy for breast cancer prevention. Direct translation of this work has been stymied by the anatomical differences between rodents (one duct per teat) and women (5–9 ductal systems per breast). The objective of thi...