NEDD9 depletion leads to MMP14 inactivation by TIMP2 and prevents invasion and metastasis

• Published in: Molecular cancer research Vol. 12; no. 1; pp. 69 - 81
• Main Authors: McLaughlin, Sarah L, Ice, Ryan J, Rajulapati, Anuradha, Kozyulina, Polina Y, Livengood, Ryan H, Kozyreva, Varvara K, Loskutov, Yuriy V, Culp, Mark V, Weed, Scott A, Ivanov, Alexey V, Pugacheva, Elena N
• Format: Journal Article
• Language: English
• Published: United States 01.01.2014
• Subjects: Adaptor Proteins, Signal Transducing - biosynthesis; Adaptor Proteins, Signal Transducing - genetics; Animals; Breast Neoplasms - genetics; Breast Neoplasms - pathology; Carcinoma in Situ - genetics; Cell Line, Tumor; Female; Humans; Lung Neoplasms - genetics; Lung Neoplasms - pathology; Lung Neoplasms - secondary; Matrix Metalloproteinase 14 - genetics; Matrix Metalloproteinase 14 - metabolism; Matrix Metalloproteinase 2 - metabolism; Matrix Metalloproteinase 9 - metabolism; MCF-7 Cells; Mice; Mice, Inbred NOD; Neoplasm Invasiveness - genetics; Neoplasm Transplantation; Neoplastic Cells, Circulating; Phosphoproteins - biosynthesis; Phosphoproteins - genetics; RNA Interference; RNA, Small Interfering; Tissue Array Analysis; Tissue Inhibitor of Metalloproteinase-2 - genetics; Tissue Inhibitor of Metalloproteinase-2 - metabolism; Transplantation, Heterologous

The scaffolding protein NEDD9 is an established prometastatic marker in several cancers. Nevertheless, the molecular mechanisms of NEDD9-driven metastasis in cancers remain ill-defined. Here, using a comprehensive breast cancer tissue microarray, it was shown that increased levels of NEDD9 protein s...