Onnamide A suppresses the severe acute respiratory syndrome-coronavirus 2 infection without inhibiting 3-chymotrypsin-like cysteine protease

• Published in: Journal of biochemistry (Tokyo) Vol. 176; no. 3; p. 197
• Main Authors: Hayashi, Yasuhiro, Higa, Nanami, Yoshida, Tetsuro, Tyas, Trianda Ayuning, Mori-Yasumoto, Kanami, Yasumoto-Hirose, Mina, Tani, Hideki, Tanaka, Junichi, Jomori, Takahiro
• Format: Journal Article
• Language: English
• Published: England 03.09.2024
• Subjects: Animals; Antiviral Agents - chemistry; Antiviral Agents - pharmacology; Chlorocebus aethiops; Coronavirus 3C Proteases - antagonists & inhibitors; Coronavirus 3C Proteases - metabolism; COVID-19 - virology; COVID-19 Drug Treatment; Cysteine Proteinase Inhibitors - chemistry; Cysteine Proteinase Inhibitors - pharmacology; Humans; Porifera - chemistry; SARS-CoV-2 - drug effects; Vero Cells; Virus Internalization - drug effects; COVID-19; SARS-CoV-2; onnamide A; marine invertebrates; Theonella swinhoei

Given the continuous emergence of new variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the development of new inhibitors is necessary to enhance clinical efficacy and increase the options for combination therapy for the coronavirus disease 2019. Because marine organisms have...