Looking for a hyper polyhedron within the multidimensional space of Design Space from the results of Designs of Experiments

• Published in: Chemometrics and intelligent laboratory systems Vol. 232; p. 104712
• Main Authors: Manzon, Diane, Ghattas, Badih, Claeys-Bruno, Magalie, Declomesnil, Sophie, Carité, Christophe, Sergent, Michelle
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 15.01.2023; Elsevier
• Subjects: Design of Experiments (DoE); Design Space (DS); Mathematics; Proven Acceptable Independent Range (PAIR); Quality by Design (QbD); Quantitative Finance; Response Surface Methodology (RSM); Quality by Design (QbD); Design of Experiments (DoE); Response Surface Methodology (RSM); Proven Acceptable Independent Range (PAIR); Design Space (DS)

In pharmaceutical studies, the Quality by Design (QbD) approach is increasingly being implemented to improve product development. Product quality is tested at each step of the manufacturing process, allowing a better process understanding and a better risk management, thus avoiding manufacturing def...