Long Noncoding RNA RUNXOR Promotes Myeloid-Derived Suppressor Cell Expansion and Functions via Enhancing Immunosuppressive Molecule Expressions during Latent HIV Infection

• Published in: The Journal of immunology (1950) Vol. 206; no. 9; pp. 2052 - 2060
• Main Authors: Zhang, Jinyu, Thakuri, Bal Krishna Chand, Zhao, Juan, Nguyen, Lam N, Nguyen, Lam N T, Khanal, Sushant, Cao, Dechao, Dang, Xindi, Schank, Madison, Lu, Zeyuan, Wu, Xiao Y, Morrison, Zheng D, El Gazzar, Mohamed, Jiang, Yong, Ning, Shunbin, Wang, Ling, Moorman, Jonathan P, Yao, Zhi Q
• Format: Journal Article
• Language: English
• Published: United States 01.05.2021
• Subjects: Arginase - genetics; Arginase - metabolism; Cell Differentiation - genetics; Cell Proliferation - genetics; Cells, Cultured; Core Binding Factor Alpha 2 Subunit - genetics; Core Binding Factor Alpha 2 Subunit - metabolism; Gene Expression Regulation; HIV Infections - drug therapy; HIV Infections - genetics; HIV Infections - metabolism; Humans; Myeloid-Derived Suppressor Cells - cytology; Myeloid-Derived Suppressor Cells - metabolism; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; RNA, Long Noncoding - genetics; Signal Transduction - genetics; STAT3 Transcription Factor - genetics; STAT3 Transcription Factor - metabolism; Up-Regulation

RUNX1 overlapping RNA (RUNXOR) is a long noncoding RNA and a key regulator of myeloid-derived suppressor cells (MDSCs) via targeting runt-related transcription factor 1 (RUNX1). We and others have previously reported MDSC expansion and inhibition of host immune responses during viral infections; how...