Effective immunotherapy of cancer in MUC1-transgenic mice using clonal cytotoxic T lymphocytes directed against an immunodominant MUC1 epitope

• Published in: Journal of immunotherapy (1997) Vol. 25; no. 1; p. 46
• Main Authors: Heukamp, Lukas C, van Hall, Thorbald, Ossendorp, Ferry, Burchell, Joy M, Melief, Cornelis J M, Taylor-Papadimitriou, Joyce, Offringa, Rienk
• Format: Journal Article
• Language: English
• Published: United States 01.01.2002
• Subjects: Amino Acid Sequence; Animals; ATP-Binding Cassette Sub-Family B Member 2; ATP-Binding Cassette Transporters - physiology; Autoimmunity; COS Cells; Cysteine Endopeptidases - physiology; Epitopes, T-Lymphocyte; Histocompatibility Antigens Class I - immunology; Immune Tolerance; Immunodominant Epitopes; Immunotherapy, Adoptive; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Transgenic; Molecular Sequence Data; Mucin-1 - chemistry; Mucin-1 - immunology; Multienzyme Complexes - physiology; Neoplasms, Experimental - immunology; Neoplasms, Experimental - therapy; Proteasome Endopeptidase Complex; T-Lymphocytes, Cytotoxic - immunology

The tumor-associated autoantigen MUCI is intensively studied as a potential target for antigen-specific immunotherapy of cancer. Previous reports concerning experiments in preclinical murine tumor models have provided evidence supporting the feasibility of this approach. However, such studies have n...