Infectivity of Plasmodium falciparum sporozoites determines emerging parasitemia in infected volunteers

• Published in: Science translational medicine Vol. 9; no. 395
• Main Authors: McCall, Matthew B B, Wammes, Linda J, Langenberg, Marijke C C, van Gemert, Geert-Jan, Walk, Jona, Hermsen, Cornelus C, Graumans, Wouter, Koelewijn, Rob, Franetich, Jean-François, Chishimba, Sandra, Gerdsen, Max, Lorthiois, Audrey, van de Vegte, Marga, Mazier, Dominique, Bijker, Else M, van Hellemond, Jaap J, van Genderen, Perry J J, Sauerwein, Robert W
• Format: Journal Article
• Language: English
• Published: United States 21.06.2017
• Subjects: Female; Hepatocytes - parasitology; Humans; Malaria, Falciparum - blood; Malaria, Falciparum - parasitology; Parasitemia - blood; Parasitemia - parasitology; Plasmodium falciparum - pathogenicity; Retrospective Studies; Sporozoites - pathogenicity; Volunteers

Malaria sporozoites must first undergo intrahepatic development before a pathogenic blood-stage infection is established. The success of infection depends on host and parasite factors. In healthy human volunteers undergoing controlled human malaria infection (CHMI), we directly compared three clinic...