A common single nucleotide polymorphism A118G of the μ opioid receptor alters its N-glycosylation and protein stability

• Published in: Biochemical journal Vol. 441; no. 1; p. 379
• Main Authors: Huang, Peng, Chen, Chongguang, Mague, Stephen D, Blendy, Julie A, Liu-Chen, Lee-Yuan
• Format: Journal Article
• Language: English
• Published: England 01.01.2012
• Subjects: Amino Acid Sequence; Animals; CHO Cells; Cricetinae; Gene Expression Regulation - physiology; Glycosylation; Humans; Mice; Mice, Knockout; Polymorphism, Single Nucleotide; Protein Stability; Receptors, Opioid, mu - genetics; Receptors, Opioid, mu - metabolism

The A118G SNP (single nucleotide polymorphism) of the hMOPR [human MOPR (μ opioid receptor)] gene OPRM1 results in an amino acid substitution (N40D). Subjects homozygous for the 118G allele have been reported to require higher morphine doses to achieve adequate analgesia, and the 118G allele is more...