Stimulation of the Nonneuronal Cholinergic System by Highly Diluted Acetylcholine in Keratinocytes

• Published in: Cells, tissues, organs Vol. 203; no. 4; p. 215
• Main Authors: Uberti, Francesca, Bardelli, Claudio, Morsanuto, Vera, Ghirlanda, Sabrina, Cochis, Andrea, Molinari, Claudio
• Format: Journal Article
• Language: English
• Published: Switzerland 01.01.2017
• Subjects: Acetylcholine - pharmacology; Calcium Signaling - drug effects; Cell Movement - drug effects; Cell Proliferation - drug effects; Cell Survival - drug effects; Humans; Keratinocytes - cytology; Keratinocytes - drug effects; Keratinocytes - metabolism; Male; Membrane Potential, Mitochondrial - drug effects; Non-Neuronal Cholinergic System - drug effects; Oxygen Consumption - drug effects; Reactive Oxygen Species - metabolism; Receptors, Muscarinic - metabolism; Signal Transduction - drug effects; Solutions

The physiological effects of acetylcholine on keratinocytes depend on the presence of nicotinic and muscarinic receptors. The role of nonneuronal acetylcholine in keratinocytes could have important clinical implications for patients with various skin disorders such as nonhealing wounds. In order to...