Mutation of the Drosophila vesicular GABA transporter disrupts visual figure detection

• Published in: Journal of experimental biology Vol. 213; no. Pt 10; pp. 1717 - 1730
• Main Authors: Fei, Hao, Chow, Dawnis M, Chen, Audrey, Romero-Calderón, Rafael, Ong, Wei S, Ackerson, Larry C, Maidment, Nigel T, Simpson, Julie H, Frye, Mark A, Krantz, David E
• Format: Journal Article
• Language: English
• Published: England Company of Biologists 15.05.2010
• Subjects: Alleles; Amino Acid Sequence; Animals; Behavior, Animal; Brain - cytology; Brain - metabolism; Drosophila melanogaster - metabolism; Drosophila Proteins - chemistry; Drosophila Proteins - genetics; Drosophila Proteins - metabolism; Fixation, Ocular - physiology; Ganglia - cytology; Ganglia - metabolism; Gene Knockdown Techniques; Larva - cytology; Larva - metabolism; Mice; Molecular Sequence Data; Movement - physiology; Mutation - genetics; Protein Transport; Synaptic Vesicles - metabolism; Transgenes - genetics; Vesicular Inhibitory Amino Acid Transport Proteins - chemistry; Vesicular Inhibitory Amino Acid Transport Proteins - genetics; Vesicular Inhibitory Amino Acid Transport Proteins - metabolism; Visual Perception - physiology

The role of gamma amino butyric acid (GABA) release and inhibitory neurotransmission in regulating most behaviors remains unclear. The vesicular GABA transporter (VGAT) is required for the storage of GABA in synaptic vesicles and provides a potentially useful probe for inhibitory circuits. However,...