Exploration of the molecular mechanisms, shared gene signatures, and MicroRNAs between systemic lupus erythematosus and diffuse large B cell lymphoma by bioinformatics analysis

• Published in: Lupus Vol. 31; no. 11; pp. 1317 - 1327
• Main Authors: Peng, Zhishen, Liang, Xiaofeng, Lin, Xiaobing, Lin, Weiyi, Lin, Zien, Wei, Shanshan
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.10.2022; Sage Publications Ltd
• Subjects: Autoimmune diseases; B-cell lymphoma; Bioinformatics; Computer programs; DNA microarrays; Gene expression; Lupus; Lymphoma; MicroRNAs; miRNA; Molecular modelling; NF-κB protein; Pathophysiology; Systemic lupus erythematosus; Therapeutic targets; diagnostic markers; miRNA; systemic lupus erythematosus; diffuse large B cell lymphoma; NF-κB pathway

Background Systemic lupus erythematosus (SLE) is a complex heterogeneous systemic autoimmune disease. Previous studies have shown that SLE may be related to diffuse large B cell lymphoma (DLBCL), but the mechanism of their relationship is still unclear. The present study aimed to explore the common...