Gender specific influence of fish oil or atorvastatin on functional properties of renal Na,K-ATPase in healthy Wistar and hypertriglyceridemic rats

• Published in: Physiological research Vol. 60; no. 6; pp. 887 - 897
• Main Authors: Vrbjar, N, Mézešová, L, Javorková, V, Vlkovičová, J, Mitašíková, M, Dlugošová, K, Okruhlicová, L, Tribulová, N
• Format: Journal Article
• Language: English
• Published: Czech Republic Institute of Physiology 01.01.2011
• Subjects: Adenosine Triphosphate - metabolism; Animals; Anticholesteremic Agents; Atherosclerosis; Atorvastatin; Binding sites; Blood pressure; Clinical trials; Diet; Enzyme kinetics; Experiments; Fatty acids; Female; Females; Fish oils; Fish Oils - pharmacology; Fish Oils - therapeutic use; Gender; Heptanoic Acids - pharmacology; Hypertriglyceridemia - drug therapy; Hypertriglyceridemia - metabolism; Kidney - enzymology; Kidney - metabolism; Laboratory animals; Lipids; Male; Males; Mortality; Nutrition research; Pyrroles - pharmacology; Rats; Rats, Inbred Strains; Rats, Wistar; Rodents; Sex Factors; Sodium-Potassium-Exchanging ATPase - metabolism; Studies

For better understanding of pathophysiological processes leading to increased retention of sodium as a consequence of hyperlipidemia, the properties of renal Na,K-ATPase, a key enzyme involved in maintaining sodium homeostasis in the organism, were studied. Enzyme kinetics of renal Na,K-ATPase were...