Single-index models with functional connectivity network predictors

• Published in: Biostatistics (Oxford, England) Vol. 24; no. 1; pp. 52 - 67
• Main Authors: Weaver, Caleb, Xiao, Luo, Lindquist, Martin A
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 12.12.2022
• Subjects: Brain - diagnostic imaging; Brain - physiology; Computer Simulation; Connectome - methods; Humans; Magnetic Resonance Imaging - methods; Nerve Net - diagnostic imaging; Nerve Net - physiology; Networks; fMRI; Penalized splines; Sparsity; Nonparametric regression

Functional connectivity is defined as the undirected association between two or more functional magnetic resonance imaging (fMRI) time series. Increasingly, subject-level functional connectivity data have been used to predict and classify clinical outcomes and subject attributes. We propose a single...