A Phase I and Pharmacokinetic Study of Lapatinib in Combination with Letrozole in Patients with Advanced Cancer - Chu, Quincy S.C.; Cianfrocca, Mary E.; Goldstein, Lori J.; Gale, Meg; Murray, Nicholas; Loftiss, Jill; Arya, Nikita; Koch, Kevin M.; Pandite, Lini; Fleming, Ronald A.; Paul, Elaine; Rowinsky, Eric K. (Clinical cancer research, 2008)
Keywords: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols - pharmacokinetics; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Area Under Curve; Breast Neoplasms - drug therapy; dose escalation; Female; Humans; lapatinib; letrozole; Male; Maximum Tolerated Dose; Middle Aged; Neoplasms - drug therapy; Nitriles - administration & dosage; Nitriles - adverse effects; Nitriles - pharmacokinetics; Ovarian Neoplasms - drug therapy; pharmacokinetics; phase I; Quinazolines - administration & dosage; Quinazolines - adverse effects; Quinazolines - pharmacokinetics; Triazoles - administration & dosage; Triazoles - adverse effects; Triazoles - pharmacokinetics