Analytical models of calcium binding in a calcium channel

• Published in: The Journal of chemical physics Vol. 141; no. 7; p. 075102
• Main Authors: Liu, Jinn-Liang, Eisenberg, Bob
• Format: Journal Article
• Language: English
• Published: United States 21.08.2014
• Subjects: Binding Sites; Calcium - metabolism; Calcium Channels - chemistry; Calcium Channels - metabolism; Models, Molecular; Poisson Distribution; Protein Binding; Protein Conformation

The anomalous mole fraction effect of L-type calcium channels is analyzed using a Fermi like distribution with the experimental data of Almers and McCleskey [J. Physiol. 353, 585 (1984)] and the atomic resolution model of Lipkind and Fozzard [Biochemistry 40, 6786 (2001)] of the selectivity filter o...