Utility of Circulating Free DNA Fragmentomics in the Prediction of Pathological Response after Neoadjuvant Chemoradiotherapy in Locally Advanced Rectal Cancer

• Published in: Clinical chemistry (Baltimore, Md.) Vol. 69; no. 1; pp. 88 - 99
• Main Authors: Wang, Yaqi, Fan, Xiaojun, Bao, Hua, Xia, Fan, Wan, Juefeng, Shen, Lijun, Wang, Yan, Zhang, Hui, Wei, Yulin, Wu, Xue, Shao, Yang, Li, Xinxiang, Xu, Ye, Cai, Sanjun, Zhang, Zhen
• Format: Journal Article
• Language: English
• Published: England 04.01.2023
• Subjects: Cell-Free Nucleic Acids - genetics; Chemoradiotherapy; DNA; Humans; Neoadjuvant Therapy; Rectal Neoplasms - drug therapy; Rectal Neoplasms - therapy; Retrospective Studies; Treatment Outcome
• ISSN: 0009-9147; 1530-8561; 1530-8561
• DOI: 10.1093/clinchem/hvac173

A "Watch and Wait" (W&W) approach has become an alternative to surgery for locally advanced rectal cancer (LARC) after neoadjuvant chemoradiotherapy (nCRT). Precise prediction of pathological complete response (pCR) will improve patient selection for W&W. We investigated the utilit...