Antiviral dynamics and sex differences of zidovudine and lamivudine triphosphate concentrations in HIV-infected individuals

• Published in: AIDS (London) Vol. 17; no. 15; pp. 2159 - 2168
• Main Authors: Anderson, Peter L, Kakuda, Thomas N, Kawle, Sagar, Fletcher, Courtney V
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 17.10.2003
• Subjects: Adult; Anti-HIV Agents - pharmacokinetics; Anti-HIV Agents - therapeutic use; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antiviral agents; Biological and medical sciences; CD4 Lymphocyte Count - methods; Chromatography, High Pressure Liquid - methods; Cytidine Triphosphate - analogs & derivatives; Cytidine Triphosphate - pharmacokinetics; Cytidine Triphosphate - therapeutic use; Dideoxynucleotides; Female; Half-Life; HIV Infections - blood; HIV Infections - drug therapy; HIV Infections - virology; Human viral diseases; Humans; Immunoassay - methods; Infectious diseases; Lamivudine - analogs & derivatives; Lamivudine - pharmacokinetics; Lamivudine - therapeutic use; Male; Medical sciences; Pharmacology. Drug treatments; Prospective Studies; Reverse Transcriptase Inhibitors - pharmacokinetics; Reverse Transcriptase Inhibitors - therapeutic use; RNA, Viral - blood; Severity of Illness Index; Sex Factors; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Zidovudine - pharmacokinetics; Zidovudine - therapeutic use; pharmacodynamics; Adherence; Mononuclear cell; Reverse transcriptase inhibitor; Antiviral; Nucleoside; phosphorylation; Human; Characteristic; Retroviridae; Enzyme inhibitor; AIDS; Liquid chromatography; Triphosphates; Method; Lentivirus; Infection; Virus; Peptidases; Nucleotidyltransferases; Blood cell; clinical pharmacology; Nucleosidic analog; Human immunodeficiency virus; triphosphate; Performance evaluation; RNA-directed DNA polymerase; antiretroviral therapy; Sex; Microbiological investigation; pharmacokinetics; Adult; Pyrimidine nucleoside; Indinavir; Immunopathology; Multiple; Enzyme; Transferases; Use; Lamivudine; nucleoside analog reverse transcriptase inhibitor; Concentration; Immune deficiency; HIV; Viral disease; Dideoxynucleoside; Hydrolases; Intracellular; Zidovudine; Protease inhibitor

Nucleoside analog reverse transcriptase inhibitors (NRTI) are used in virtually all anti-HIV regimens. Clinical response depends on the intracellular formation of the pharmacologically active triphosphate moiety. Our objective was to quantify the pharmacological characteristics of zidovudine and lam...