Association between Polymorphisms in DNA Base Excision Repair Genes XRCC1, APE1, and ADPRT and Differentiated Thyroid Carcinoma

• Published in: Clinical cancer research Vol. 14; no. 18; pp. 5919 - 5924
• Main Authors: Chiang, Feng-Yu, Wu, Che-Wei, Hsiao, Pi-Jung, Kuo, Wen-Rei, Lee, Ka-Wo, Lin, Jen-Chih, Liao, Yi-Chu, Juo, Suh-Hang Hank
• Format: Journal Article
• Language: English
• Published: United States American Association for Cancer Research 15.09.2008
• Subjects: ADP Ribose Transferases - genetics; Adult; Case-Control Studies; differentiated thyroid carcinoma; DNA BER SNPs; DNA Repair; DNA-(Apurinic or Apyrimidinic Site) Lyase - genetics; DNA-Binding Proteins - genetics; Female; Humans; Lymphatic Metastasis; Male; Middle Aged; Polymorphism, Single Nucleotide; Thyroid Neoplasms - genetics; Thyroid Neoplasms - pathology; X-ray Repair Cross Complementing Protein 1

Purpose: DNA BER pathway is related with carcinogenesis. We hypothesized that functional polymorphisms of three BER genes, XRCC1, apurinic/apyrimidinic endonuclease ( APE1 ), and ADPRT , confer risks for DTC and its progression. Experimental Design: Five common nonsynonymous single nucleotide polymo...