Disassociation of the macrophage-maturational effects of vitamin D from respiratory burst priming

• Published in: The Journal of biological chemistry Vol. 266; no. 17; pp. 10888 - 10892
• Main Authors: TANAKA, H, KRUSKA, K. A, SEINO, Y, MALONE, J. D, NISHII, Y, TEITELBAUM, S. L
• Format: Journal Article
• Language: English
• Published: Bethesda, MD American Society for Biochemistry and Molecular Biology 15.06.1991
• Subjects: Antineoplastic Agents - pharmacology; Biological and medical sciences; Calcitriol - analogs & derivatives; Calcitriol - metabolism; Calcitriol - pharmacology; Calcium - metabolism; Cell Differentiation - drug effects; Cell differentiation, maturation, development, hematopoiesis; Cell Line; Cell physiology; Cytoplasm - metabolism; Fundamental and applied biological sciences. Psychology; Humans; Leukemia, Promyelocytic, Acute; Macrophages - cytology; Macrophages - drug effects; Molecular and cellular biology; N-Formylmethionine Leucyl-Phenylalanine - pharmacology; Receptors, Calcitriol; Receptors, Formyl Peptide; Receptors, Immunologic - drug effects; Receptors, Immunologic - metabolism; Receptors, Steroid - drug effects; Receptors, Steroid - metabolism; Superoxides - metabolism; Tetradecanoylphorbol Acetate - pharmacology; Human; Signal transduction; Calcium; Vitamin D; Reaction mechanism; Respiratory burst; Cell differentiation; Macrophage

During the process of enhancing monocytic differentiation of the human leukemia line HL-60, 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) also "primes" the cell for respiratory burst by increasing the uptake of Ca2+ across the plasma membrane (Hruska, K.A., Bar-Shavit, Z., Malone, J.D., and Teite...