Cutting Edge: Enhanced Clonal Burst Size Corrects an Otherwise Defective Memory Response by CD8+ Recent Thymic Emigrants

• Published in: The Journal of immunology (1950) Vol. 196; no. 6; pp. 2450 - 2455
• Main Authors: Deets, Katherine A, Berkley, Amy M, Bergsbaken, Tessa, Fink, Pamela J
• Format: Journal Article
• Language: English
• Published: United States 15.03.2016
• Subjects: Adoptive Transfer; Animals; CD8-Positive T-Lymphocytes - cytology; CD8-Positive T-Lymphocytes - immunology; Cell Differentiation - immunology; Cell Separation; Flow Cytometry; Immunologic Memory - immunology; Lymphocyte Activation - immunology; Mice; Mice, Transgenic; Thymus Gland - cytology; Thymus Gland - immunology

The youngest peripheral T cells (recent thymic emigrants [RTEs]) are functionally distinct from naive T cells that have completed postthymic maturation. We assessed the RTE memory response and found that RTEs produced less granzyme B than their mature counterparts during infection but proliferated m...