Oxygen and Iron Availability Shapes Metabolic Adaptations of Cancer Cells
The dynamic changes between glycolysis and oxidative phosphorylation (OXPHOS) for adenosine triphosphate (ATP) output, along with glucose, glutamine, and fatty acid utilization, etc., lead to the maintenance and selection of growth advantageous to tumor cell subgroups in an environment of iron starv...
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Published in | World journal of oncology Vol. 15; no. 1; pp. 28 - 37 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Canada
Elmer Press
01.02.2024
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Subjects | |
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Abstract | The dynamic changes between glycolysis and oxidative phosphorylation (OXPHOS) for adenosine triphosphate (ATP) output, along with glucose, glutamine, and fatty acid utilization, etc., lead to the maintenance and selection of growth advantageous to tumor cell subgroups in an environment of iron starvation and hypoxia. Iron plays an important role in the three major biochemical reactions in nature: photosynthesis, nitrogen fixation, and oxidative respiration, which all require the participation of iron-sulfur proteins, such as ferredoxin, cytochrome b, and the complex I, II, III in the electron transport chain, respectively. Abnormal iron-sulfur cluster synthesis process or hypoxia will directly affect the function of mitochondrial electron transfer and mitochondrial OXPHOS. More research results have indicated that iron metabolism, oxygen availability and hypoxia-inducible factor mutually regulate the shift between glycolysis and OXPHOS. In this article, we make a perspective review to provide novel opinions of the regulation of glycolysis and OXPHOS in tumor cells. |
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AbstractList | The dynamic changes between glycolysis and oxidative phosphorylation (OXPHOS) for adenosine triphosphate (ATP) output, along with glucose, glutamine, and fatty acid utilization, etc., lead to the maintenance and selection of growth advantageous to tumor cell subgroups in an environment of iron starvation and hypoxia. Iron plays an important role in the three major biochemical reactions in nature: photosynthesis, nitrogen fixation, and oxidative respiration, which all require the participation of iron-sulfur proteins, such as ferredoxin, cytochrome b, and the complex I, II, III in the electron transport chain, respectively. Abnormal iron-sulfur cluster synthesis process or hypoxia will directly affect the function of mitochondrial electron transfer and mitochondrial OXPHOS. More research results have indicated that iron metabolism, oxygen availability and hypoxia-inducible factor mutually regulate the shift between glycolysis and OXPHOS. In this article, we make a perspective review to provide novel opinions of the regulation of glycolysis and OXPHOS in tumor cells. |
Author | Jin, Xiao Wei Wang, Miao Miao Hussain, Aashiq Wang, Rui Guo, Quan Quan |
AuthorAffiliation | b Department of Hematology, the Second Affiliated Hospital of Soochow University, Su Zhou City, China a Department of Oncology, Suqian Affiliated Hospital of Xuzhou Medical University, Suqian City, China e Department of General Surgery, Suqian Affiliated Hospital of Xuzhou Medical University, Suqian City, China c Cancer Science Institute of Singapore, National University of Singapore, 119077 Singapore d Department of Radiology, the Second Affiliated Hospital of Soochow University, Su Zhou City, China |
AuthorAffiliation_xml | – name: d Department of Radiology, the Second Affiliated Hospital of Soochow University, Su Zhou City, China – name: b Department of Hematology, the Second Affiliated Hospital of Soochow University, Su Zhou City, China – name: e Department of General Surgery, Suqian Affiliated Hospital of Xuzhou Medical University, Suqian City, China – name: a Department of Oncology, Suqian Affiliated Hospital of Xuzhou Medical University, Suqian City, China – name: c Cancer Science Institute of Singapore, National University of Singapore, 119077 Singapore |
Author_xml | – sequence: 1 givenname: Rui surname: Wang fullname: Wang, Rui organization: Department of Hematology, the Second Affiliated Hospital of Soochow University, Su Zhou City, China – sequence: 2 givenname: Aashiq surname: Hussain fullname: Hussain, Aashiq organization: Cancer Science Institute of Singapore, National University of Singapore, 119077 Singapore – sequence: 3 givenname: Quan Quan surname: Guo fullname: Guo, Quan Quan organization: Department of Radiology, the Second Affiliated Hospital of Soochow University, Su Zhou City, China – sequence: 4 givenname: Xiao Wei surname: Jin fullname: Jin, Xiao Wei organization: Department of Oncology, Suqian Affiliated Hospital of Xuzhou Medical University, Suqian City, China – sequence: 5 givenname: Miao Miao surname: Wang fullname: Wang, Miao Miao organization: Department of General Surgery, Suqian Affiliated Hospital of Xuzhou Medical University, Suqian City, China |
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Copyright | Copyright 2024, Wang et al. Copyright 2024, Wang et al. 2024 |
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Keywords | Glycolysis OXPHOS Tumor Oxygen Iron Metabolism |
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Title | Oxygen and Iron Availability Shapes Metabolic Adaptations of Cancer Cells |
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