A Simple Plasma Retinol Isotope Ratio Method for Estimating β-Carotene Relative Bioefficacy in Humans: Validation with the Use of Model-Based Compartmental Analysis

• Published in: The Journal of nutrition Vol. 147; no. 9; pp. 1806 - 1814
• Main Authors: Ford, Jennifer Lynn, Green, Joanne Balmer, Lietz, Georg, Oxley, Anthony, Green, Michael H
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.09.2017
• Subjects: beta Carotene - metabolism; beta Carotene - pharmacokinetics; bioconversion; bioefficacy; Biological Availability; carotenoids; Diterpenes; Humans; Intestinal Absorption; isotope reference method; Isotopes - metabolism; model-based compartmental analysis; Models, Biological; Provitamins - metabolism; retinoids; retinol isotope ratio; Retinyl Esters; Vitamin A - analogs & derivatives; Vitamin A - biosynthesis; Vitamin A - blood; Vitamin A - metabolism; WinSAAM; β-carotene; carotenoids; IRM; bioconversion; β-carotene; model-based compartmental analysis; WinSAAM; isotope reference method; bioefficacy; FDp; retinol isotope ratio; RIR; humans; retinoids; AUCp

Provitamin A carotenoids are an important source of dietary vitamin A for many populations. Thus, accurate and simple methods for estimating carotenoid bioefficacy are needed to evaluate the vitamin A value of test solutions and plant sources. β-Carotene bioefficacy is often estimated from the ratio...