A non-classical PUF family protein in oomycetes functions as a pre-rRNA processing regulator and a target for RNAi-based disease control

• Published in: PLoS pathogens Vol. 21; no. 7; p. e1013379
• Main Authors: Feng, Hui, Liu, Tianli, Wan, Chuanxu, Zhang, Zhichao, Wang, Yuanchao, Zheng, Xiaobo, Wang, Jie, Ye, Wenwu
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 31.07.2025; Public Library of Science (PLoS)
• Subjects: Biology and Life Sciences; Oomycetes - genetics; Oomycetes - metabolism; Oomycetes - pathogenicity; Phytophthora - genetics; Phytophthora - metabolism; Phytophthora - pathogenicity; Plant Diseases - microbiology; Plant Diseases - prevention & control; Pythium - genetics; Pythium - metabolism; Pythium - pathogenicity; Research and Analysis Methods; RNA Interference; RNA Precursors - genetics; RNA Precursors - metabolism; RNA Processing, Post-Transcriptional; RNA-Binding Proteins - genetics; RNA-Binding Proteins - metabolism

Ribosome biogenesis is an essential and tightly regulated process linked to cell proliferation and growth. However, its regulatory mechanisms in oomycetes, a group of organisms with significant agricultural and ecological importance, remain unclear. In this study, we identify Puf4, a non-classical P...