Brief Report: Decreased JC Virus-Specific Antibody-Dependent Cellular Cytotoxicity in HIV-Seropositive PML Survivors

• Published in: Journal of acquired immune deficiency syndromes (1999) Vol. 82; no. 2; p. 220
• Main Authors: Tan, Chen S, Ghofrani, Joshua, Geiger, Emma, Koralnik, Igor J, Jost, Stephanie
• Format: Journal Article
• Language: English
• Published: United States 01.10.2019
• Subjects: Adult; Antibodies, Viral - blood; Antibodies, Viral - immunology; Antibody-Dependent Cell Cytotoxicity - immunology; Capsid Proteins - immunology; env Gene Products, Human Immunodeficiency Virus - immunology; Female; HIV Infections - immunology; Humans; JC Virus - immunology; Leukoencephalopathy, Progressive Multifocal - immunology; Male; Middle Aged
• ISSN: 1944-7884
• DOI: 10.1097/QAI.0000000000002105

Progressive multifocal leukoencephalopathy (PML) is an often fatal disease caused by JC virus (JCV) in severely immunocompromised patients, including HIV patients. Development of therapeutics to prevent or treat PML is an urgent medical need. While JCV-specific T cells are crucial to control JCV and...