Single-cell RNA sequencing reveals the landscape of early female germ cell development

• Published in: The FASEB journal Vol. 34; no. 9; p. 12634
• Main Authors: Zhao, Zheng-Hui, Ma, Jun-Yu, Meng, Tie-Gang, Wang, Zhen-Bo, Yue, Wei, Zhou, Qian, Li, Sen, Feng, Xie, Hou, Yi, Schatten, Heide, Ou, Xiang-Hong, Sun, Qing-Yuan
• Format: Journal Article
• Language: English
• Published: United States 01.09.2020
• Subjects: Animals; Cell Differentiation; Female; Gene Expression Regulation, Developmental; Meiosis; Mice; Mice, Inbred C57BL; Mitosis; Oogenesis; Oogonia - cytology; Ovary - cytology; Sequence Analysis, RNA; Single-Cell Analysis; Transcriptome; scRNA-seq; developmental trajectory; oocyte; meiosis initiation

Meiosis initiation is a crucial step for the production of haploid gametes, which occurs from anterior to posterior in fetal ovaries. The asynchrony of the transition from mitosis to meiosis results in heterogeneity in the female germ cell populations, which limits the studies of meiosis initiation...