Uukuniemi virus infection causes a pervasive remodelling of the RNA-binding proteome in tick cells

• Published in: PLoS pathogens Vol. 21; no. 8; p. e1013393
• Main Authors: Wilson, Alexandra, Kamel, Wael, Davies, Kelsey, De Laurent, Zaydah R., Arif, Rozeena, Clarke, Andrew T., Bell-Sakyi, Lesley, Lamont, Douglas, Demyanenko, Yana, Noerenberg, Marko, Kohl, Alain, Mohammed, Shabaz, Castello, Alfredo, Brennan, Benjamin
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 04.08.2025; Public Library of Science (PLoS)
• Subjects: Animals; Biology and Life Sciences; Bunyaviridae Infections - metabolism; Bunyaviridae Infections - virology; Host-Pathogen Interactions; Medicine and Health Sciences; Nucleocapsid Proteins - metabolism; Orthobunyavirus - physiology; Proteome - metabolism; Research and Analysis Methods; RNA-Binding Proteins - genetics; RNA-Binding Proteins - metabolism; Ticks - metabolism; Ticks - virology

Cellular RNA-binding proteins (RBPs) are pivotal for the viral lifecycle, mediating key host-virus interactions that promote or repress virus infection. While these interactions have been largely studied in the vertebrate host, no comprehensive analyses of protein-RNA interactions occurring in cells...