cAMP-dependent protein kinase inhibits FoxO activity and regulates skeletal muscle plasticity in mice

• Published in: The FASEB journal Vol. 34; no. 9; p. 12946
• Main Authors: Silveira, Wilian A, Gonçalves, Dawit A, Machado, Juliano, Lautherbach, Natalia, Lustrino, Danilo, Paula-Gomes, Silvia, Pereira, Marcelo G, Miyabara, Elen H, Sandri, Marco, Kettelhut, Isis C, Navegantes, Luiz C
• Format: Journal Article
• Language: English
• Published: United States 01.09.2020
• Subjects: Animals; Cell Line; Cyclic AMP-Dependent Protein Kinases - metabolism; Forkhead Box Protein O1 - metabolism; Forkhead Box Protein O3 - metabolism; Male; Mice; Mice, Inbred C57BL; Muscle, Skeletal - enzymology; Muscle, Skeletal - pathology; Muscular Atrophy - metabolism; Myoblasts, Skeletal - enzymology; Signal Transduction; ubiquitin-proteasome system; skeletal muscle plasticity; skeletal muscle atrophy; adrenergic signaling; protein metabolism

Although we have shown that catecholamines suppress the activity of the Ubiquitin-Proteasome System (UPS) and atrophy-related genes expression through a cAMP-dependent manner in skeletal muscle from rodents, the underlying mechanisms remain unclear. Here, we report that a single injection of norepin...