Cyclic AMP Mediates EDHF-Type Relaxations of Rabbit Jugular Vein

• Published in: Biochemical and biophysical research communications Vol. 263; no. 1; pp. 52 - 57
• Main Authors: Griffith, T.M., Taylor, H.J.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 16.09.1999
• Subjects: 3′:5′-cyclic adenosine monophosphate; acetylcholine; Acetylcholine - pharmacology; Animals; Biological Factors - physiology; Colforsin - pharmacology; Cyclic AMP - physiology; Endothelium, Vascular - physiology; endothelium-dependent hyperpolarizing factor; gap junctions; Gap Junctions - physiology; Glycyrrhetinic Acid - analogs & derivatives; Glycyrrhetinic Acid - pharmacology; In Vitro Techniques; Indomethacin - pharmacology; Jugular Veins - drug effects; Jugular Veins - physiology; Male; Models, Biological; Muscle Relaxation - drug effects; Muscle Relaxation - physiology; Muscle, Smooth, Vascular - physiology; NG-Nitroarginine Methyl Ester - pharmacology; Rabbits; Vasodilation - drug effects; Vasodilation - physiology; Vasodilator Agents - pharmacology; gap junctions; acetylcholine; endothelium-dependent hyperpolarizing factor; 3′:5′-cyclic adenosine monophosphate

Isolated rings of rabbit jugular vein have been used to test the hypothesis that formation of cAMP within the endothelial cell contributes to relaxations that are attributable to the endothelium-derived hyperpolarizing factor, EDHF. Relaxations induced by acetylcholine under conditions of combined N...