The Expression of TGF-β Receptors in Human Atherosclerosis: Evidence for Acquired Resistance to Apoptosis due to Receptor Imbalance

• Published in: Journal of molecular and cellular cardiology Vol. 31; no. 9; pp. 1627 - 1642
• Main Authors: McCaffrey, Timothy A, Du, Baoheng, Fu, Chenzhong, Bray, Paula J, Sanborn, Timothy A, Deutsch, Ezra, Tarazona, Norman, Shaknovitch, Alexander, Newman, Gregg, Patterson, Cam, Bush Jr, Harry L
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.09.1999
• Subjects: Activin Receptors, Type I; Apoptosis; Arteriosclerosis - genetics; Arteriosclerosis - pathology; Arteriosclerosis - physiopathology; Atherectomy; Atherosclerosis; Carotid Stenosis - genetics; Carotid Stenosis - pathology; Carotid Stenosis - physiopathology; Cell Division - drug effects; Cloning, Molecular; Coronary Disease - genetics; Coronary Disease - pathology; Coronary Disease - physiopathology; Endarterectomy, Carotid; Gene therapy; Humans; Immunohistochemistry; Interferon-γ; Models, Cardiovascular; Protein-Serine-Threonine Kinases - genetics; Receptors; Receptors, Transforming Growth Factor beta - genetics; Recombinant Proteins - biosynthesis; Recurrence; Resistance; Restenosis; Retrovirus; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger - genetics; Transcription, Genetic; Transfection; Transforming Growth Factor beta - pharmacology; Transforming growth factor- β; Resistance; Restenosis; Retrovirus; Receptors; Interferon-γ; Atherosclerosis; Transforming growth factor- β; Gene therapy; Apoptosis

The degree of cellularity in vascular lesions is determined by the balance between the migration and proliferation of cells relative to their rate of egress and apoptosis. Transforming growth factor- β1can act as a potent antiproliferative and apoptotic factor for proliferating vascular cells. Our l...