Morin protects gastric mucosa from nonsteroidal anti-inflammatory drug, indomethacin induced inflammatory damage and apoptosis by modulating NF-κB pathway

• Published in: Biochimica et biophysica acta Vol. 1850; no. 4; pp. 769 - 783
• Main Authors: Sinha, Krishnendu, Sadhukhan, Pritam, Saha, Sukanya, Pal, Pabitra Bikash, Sil, Parames C.
• Format: Journal Article
• Language: English
• Published: Netherlands 01.04.2015
• Subjects: absorption; adhesion; adverse effects; Animals; Anti-Inflammatory Agents, Non-Steroidal - toxicity; antioxidants; Antioxidants - pharmacology; apoptosis; Apoptosis - drug effects; biosynthesis; Cyclooxygenase 2 - analysis; cytokines; enzyme-linked immunosorbent assay; enzymes; Flavonoids - pharmacology; Gastric Emptying - drug effects; gastric mucosa; Gastric Mucosa - drug effects; Gastritis - prevention & control; I-kappa B Proteins - metabolism; indomethacin; Indomethacin - toxicity; inflammation; Male; medicinal properties; Mitochondria - drug effects; NF-kappa B - physiology; NF-KappaB Inhibitor alpha; nonsteroidal anti-inflammatory agents; oxidative stress; pathogenesis; pharmacokinetics; prostaglandins; Rats; Rats, Sprague-Dawley; reverse transcriptase polymerase chain reaction; reversed-phase high performance liquid chromatography; Signal Transduction - drug effects; transcription factor NF-kappa B; Anti-inflammatory compound; Inflammation; Morin; Antioxidant; Gastropathy; NSAID

Deregulation in prostaglandin (PG) biosynthesis, severe oxidative stress, inflammation and apoptosis contribute to the pathogenesis of nonsteroidal anti-inflammatory drug (NSAID)-induced gastropathy. Unfortunately, most of the prescribed anti-ulcer drugs generate various side effects. In this scenar...