Andrographolide ameliorates diabetic retinopathy by inhibiting retinal angiogenesis and inflammation

• Published in: Biochimica et biophysica acta Vol. 1850; no. 4; pp. 824 - 831
• Main Authors: Yu, Zengyang, Lu, Bin, Sheng, Yuchen, Zhou, Lingyu, Ji, Lili, Wang, Zhengtao
• Format: Journal Article
• Language: English
• Published: Netherlands 01.04.2015
• Subjects: Andrographis paniculata; angiogenesis; Angiogenesis Inhibitors - pharmacology; Animals; Anti-Inflammatory Agents - pharmacology; blood serum; Diabetes Mellitus, Experimental; diabetic retinopathy; Diabetic Retinopathy - drug therapy; Diabetic Retinopathy - physiopathology; Diterpenes - pharmacology; Early Growth Response Protein 1 - physiology; enzyme-linked immunosorbent assay; fluorescent antibody technique; gene expression; inflammation; interleukin-1beta; interleukin-6; medicinal plants; messenger RNA; Mice; Mice, Inbred C57BL; necrosis; NF-kappa B - physiology; protein synthesis; quantitative polymerase chain reaction; Retinal Vessels - drug effects; Retinal Vessels - physiopathology; signal transduction; staining; Streptozocin; streptozotocin; transcription factor NF-kappa B; tumor necrosis factor-alpha; Vascular Endothelial Growth Factor A - analysis; Vascular Endothelial Growth Factor A - physiology; vascular endothelial growth factor receptors; vascular endothelial growth factors; Angiogenesis; Diabetic retinopathy; Inflammation; Andrographolide

Andrographolide (Andro) is the main compound distributed in medicinal herb Andrographis paniculata. This study aims to observe the amelioration of Andro on streptozotocin (STZ)-induced diabetic retinopathy (DR) in mice. STZ-induced non-proliferative DR (NPDR) for 2 months and proliferative DR (PDR)...