Andrographolide ameliorates diabetic retinopathy by inhibiting retinal angiogenesis and inflammation - Yu, Zengyang; Lu, Bin; Sheng, Yuchen; Zhou, Lingyu; Ji, Lili; Wang, Zhengtao (Biochimica et biophysica acta, 2015)
Keywords: Andrographis paniculata; angiogenesis; Angiogenesis Inhibitors - pharmacology; Animals; Anti-Inflammatory Agents - pharmacology; blood serum; Diabetes Mellitus, Experimental; diabetic retinopathy; Diabetic Retinopathy - drug therapy; Diabetic Retinopathy - physiopathology; Diterpenes - pharmacology; Early Growth Response Protein 1 - physiology; enzyme-linked immunosorbent assay; fluorescent antibody technique; gene expression; inflammation; interleukin-1beta; interleukin-6; medicinal plants; messenger RNA; Mice; Mice, Inbred C57BL; necrosis; NF-kappa B - physiology; protein synthesis; quantitative polymerase chain reaction; Retinal Vessels - drug effects; Retinal Vessels - physiopathology; signal transduction; staining; Streptozocin; streptozotocin; transcription factor NF-kappa B; tumor necrosis factor-alpha; Vascular Endothelial Growth Factor A - analysis; Vascular Endothelial Growth Factor A - physiology; vascular endothelial growth factor receptors; vascular endothelial growth factors; Angiogenesis; Diabetic retinopathy; Inflammation; Andrographolide