Characterizing responses to CFTR-modulating drugs using rectal organoids derived from subjects with cystic fibrosis - Dekkers, Johanna F; Berkers, Gitte; Kruisselbrink, Evelien; Vonk, Annelotte; de Jonge, Hugo R; Janssens, Hettie M; Bronsveld, Inez; van de Graaf, Eduard A; Nieuwenhuis, Edward E S; Houwen, Roderick H J; Vleggaar, Frank P; Escher, Johanna C; et al. (Science translational medicine, 2016)
Keywords: Aminophenols - pharmacology; Aminopyridines - pharmacology; Benzodioxoles - pharmacology; Biological Assay - methods; Chlorides - metabolism; Cystic Fibrosis - drug therapy; Cystic Fibrosis - genetics; Cystic Fibrosis - metabolism; Cystic Fibrosis Transmembrane Conductance Regulator - genetics; Cystic Fibrosis Transmembrane Conductance Regulator - metabolism; Genotype; Humans; In Vitro Techniques; Mutation - genetics; Organoids - drug effects; Organoids - metabolism; Quinolones - pharmacology