Impact of Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers on Renal Function in Type 1 Cardiorenal Syndrome

• Published in: Journal of cardiovascular pharmacology and therapeutics Vol. 26; no. 6; pp. 611 - 618
• Main Authors: Ilges, Daniel T., Dermody, Morgan L., Blankenship, Caitlyn, Mansfield, Valerie, Van Tuyl, Joseph S.
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 01.11.2021
• Subjects: Acute Kidney Injury - blood; Acute Kidney Injury - chemically induced; Acute Kidney Injury - epidemiology; Adult; Aged; Aged, 80 and over; Angiotensin Receptor Antagonists - adverse effects; Angiotensin Receptor Antagonists - therapeutic use; Angiotensin-Converting Enzyme Inhibitors - adverse effects; Angiotensin-Converting Enzyme Inhibitors - therapeutic use; Cardio-Renal Syndrome - drug therapy; Creatinine - blood; Female; Heart Failure; Hospital Mortality; Humans; Kidney - drug effects; Male; Middle Aged; Missouri - epidemiology; Retrospective Studies; Withholding Treatment; Young Adult; Missouri; cardio-renal syndrome; heart failure; angiotensin-converting enzyme inhibitors; angiotensin receptor antagonists; renal insufficiency

Introduction: Angiotensin-converting enzyme inhibitor (ACE-I) and angiotensin receptor blocker (ARB) discontinuation during acute heart failure (AHF) is associated with increased mortality following hospitalization. Although the etiology of acute kidney injury (AKI) in type 1 cardiorenal syndrome (C...