eHydrogenation: Hydrogen-free Electrochemical Hydrogenation

Hydrogenation reactions are staple transformations commonly used across scientific fields to synthesise pharmaceuticals, natural products, and various functional materials. However, the vast majority of these reactions require the use of a toxic and costly catalyst leading to unpractical, hazardous...

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Published inAngewandte Chemie International Edition Vol. 62; no. 38; p. e202309563
Main Authors Russo, Camilla, Leech, Matthew C., Walsh, Jamie M., Higham, Joe I., Giannessi, Lisa, Lambert, Emmanuelle, Kiaku, Cyrille, Poole, Darren L., Mason, Joseph, Goodall, Charles A. I., Devo, Perry, Giustiniano, Mariateresa, Radi, Marco, Lam, Kevin
Format Journal Article
LanguageEnglish
Published WEINHEIM Wiley 18.09.2023
Wiley Subscription Services, Inc
EditionInternational ed. in English
Subjects
Alkynes
Catalysts
Chemical reactions
Chemistry
Chemistry, Multidisciplinary
Deuterium
Electrochemistry
Functional materials
Hydrogenation
Labeling
Natural products
Physical Sciences
Science & Technology
OXIDATION
HYDRAZINE
DIIMIDE
REDUCTION
Electrochemistry
Diimide Reduction
Deuteration
Anodic Oxidation
Hydrogenation
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Summary:Hydrogenation reactions are staple transformations commonly used across scientific fields to synthesise pharmaceuticals, natural products, and various functional materials. However, the vast majority of these reactions require the use of a toxic and costly catalyst leading to unpractical, hazardous and often functionally limited conditions. Herein, we report a new, general, practical, efficient, mild and high-yielding hydrogen-free electrochemical method for the reduction of alkene, alkyne, nitro and azido groups. Finally, this method has been applied to deuterium labelling.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1433-7851
1521-3773
DOI:10.1002/anie.202309563