Osteopontin induced vascular endothelial growth factor production in dispersed nasal polyp cells through the phosphatidylinositol 3-kinase-protein kinase B and the extracellular signal-regulated kinase 1/2 pathways

• Published in: American journal of rhinology & allergy Vol. 31; no. 4; p. 35
• Main Authors: Du, Jingdong, Mao, Huadong, Ouyang, Hong, Xin, Yan
• Format: Journal Article
• Language: English
• Published: United States 01.07.2017
• Subjects: Adult; Cells, Cultured; Chronic Disease; Endothelial Cells - physiology; Epithelial Cells - physiology; Female; Humans; Male; MAP Kinase Signaling System; Middle Aged; Nasal Polyps - complications; Nasal Polyps - genetics; Nasal Polyps - metabolism; Neovascularization, Pathologic; Osteopontin - genetics; Osteopontin - metabolism; Phosphatidylinositol 3-Kinases - metabolism; Rhinitis - complications; Rhinitis - genetics; Rhinitis - metabolism; Sinusitis - complications; Sinusitis - genetics; Sinusitis - metabolism; Vascular Endothelial Growth Factor A - genetics; Vascular Endothelial Growth Factor A - metabolism; Young Adult

Osteopontin (OPN) is involved in cell survival, migration, and angiogenesis. The role of OPN in inducing angiogenesis in tumor has been confirmed. In this study, we investigated the expression of OPN in patients with chronic rhinosinusitis (CRS) with nasal polyp (NP) and the relationship of OPN with...