Efficient induction of CCR9 on T cells requires coactivation of retinoic acid receptors and retinoid X receptors (RXRs): exaggerated T Cell homing to the intestine by RXR activation with organotins

• Published in: The Journal of immunology (1950) Vol. 185; no. 9; pp. 5289 - 5299
• Main Authors: Takeuchi, Hajime, Yokota, Aya, Ohoka, Yoshiharu, Kagechika, Hiroyuki, Kato, Chieko, Song, Si-Young, Iwata, Makoto
• Format: Journal Article
• Language: English
• Published: United States 01.11.2010
• Subjects: Animals; Cell Separation; Chemotaxis, Leukocyte - drug effects; Chemotaxis, Leukocyte - immunology; Flow Cytometry; Intestines - immunology; Mice; Mice, Inbred BALB C; Mice, Knockout; Mice, Transgenic; Organotin Compounds - pharmacology; Receptors, CCR - biosynthesis; Receptors, CCR - immunology; Receptors, Retinoic Acid - immunology; Receptors, Retinoic Acid - metabolism; Retinoid X Receptors - immunology; Retinoid X Receptors - metabolism; Reverse Transcriptase Polymerase Chain Reaction; T-Lymphocytes, Regulatory - drug effects; T-Lymphocytes, Regulatory - immunology; T-Lymphocytes, Regulatory - metabolism

The active vitamin A metabolite retinoic acid (RA) imprints gut-homing specificity on lymphocytes upon activation by inducing the expression of α4β7 integrin and CCR9. RA receptor (RAR) activation is essential for their expression, whereas retinoid X receptor (RXR) activation is not essential for α4...