The role of miR-146a/IRAK1/JNK1 pathway in mediating the effects of Yiqi Congming decoction on dry eye: A mechanistic study in rat models - Liu, Yulin; Jiang, Yanhua; Song, Caiqiu; Zuo, Tao; Zhang, Jinghan; Zhao, Lei (Journal of ethnopharmacology, 2025)
Keywords: animal models; Animals; apoptosis; Apoptosis - drug effects; blood serum; caspase-3; cell viability; cornea; Corneal inflammation; Disease Models, Animal; Drugs, Chinese Herbal - chemistry; Drugs, Chinese Herbal - pharmacology; Drugs, Chinese Herbal - therapeutic use; Dry eye; Dry Eye Syndromes - drug therapy; Dry Eye Syndromes - genetics; Dry Eye Syndromes - metabolism; Dry Eye Syndromes - pathology; electron microscopy; epithelial cells; epithelium; fluorescein; Humans; inflammation; Interleukin-1 Receptor-Associated Kinases - genetics; Interleukin-1 Receptor-Associated Kinases - metabolism; interleukin-6; Male; mass spectrometry; MicroRNAs - genetics; MicroRNAs - metabolism; miR-146a/IRAK1/JNK1 pathway; Mitogen-Activated Protein Kinase 8 - genetics; Mitogen-Activated Protein Kinase 8 - metabolism; Oriental traditional medicine; Rats; Rats, Sprague-Dawley; Signal Transduction - drug effects; Tear film stability; therapeutics; Traditional Chinese medicine; ultra-performance liquid chromatography; Western blotting; Yiqi Congming decoction (YQCM); Traditional Chinese medicine; Tear film stability; Corneal inflammation; Dry eye; Yiqi Congming decoction (YQCM); miR-146a/IRAK1/JNK1 pathway