Vaccarin treats lactation insufficiency through the ALKBH5-SFRP2-Wnt/β-catenin signaling pathway - Xue, Qiuyun; Li, Hui; Liu, Guosheng; Xiong, Youyi; Zhou, Guoliang; Xu, Pengfei; He, Juan; Wang, Xiaomei; Miao, Chenggui (Journal of ethnopharmacology, 2025)
Keywords: AlkB Homolog 5, RNA Demethylase - genetics; AlkB Homolog 5, RNA Demethylase - metabolism; alkylation; Alkylation repair homolog protein 5; Animals; beta Catenin - metabolism; Cells, Cultured; childbirth; Epithelial Cells - drug effects; Epithelial Cells - metabolism; epithelium; Female; flavonoids; Flavonoids - pharmacology; Flavonoids - therapeutic use; fluorescent antibody technique; glycosides; Glycosides - pharmacology; Glycosides - therapeutic use; Gypsophila; lactation; Lactation - drug effects; Lactation Disorders - drug therapy; Lactation Disorders - metabolism; Lactation insufficiency; mammary glands; Mammary Glands, Animal - drug effects; Mammary Glands, Animal - metabolism; Membrane Proteins - genetics; Membrane Proteins - metabolism; Mice; milk production; milk secretion; precipitin tests; prolactin; prolactin receptors; Rats; Rats, Sprague-Dawley; RNA; SFRP2; traditional medicine; Vaccaria; Vaccarin; Western blotting; Wnt Signaling Pathway - drug effects; Wnt/β-catenin signaling pathway; Wnt/β-catenin signaling pathway; MT; Alkylation repair homolog protein 5; mRNA; PRL; WB; BMECs; MECs; PRLR; CK18; ALKBH5; Vaccarin; SFRP2; CCND1; RIP; Vac; RMECs; Lactation insufficiency