The effects of corticosteroids on the healing of tracheal anastomoses in a rat model
The deleterious effects of corticosteroids on anastomotic healing have been widely demonstrated in various tissues. This study is designed to investigate the effects of corticosteroids on the healing of tracheal anastomoses. Forty-two adult female Wistar rats, randomly divided into five groups, unde...
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Published in | Pharmacological research Vol. 45; no. 4; pp. 299 - 304 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
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Elsevier Ltd
01.04.2002
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Abstract | The deleterious effects of corticosteroids on anastomotic healing have been widely demonstrated in various tissues. This study is designed to investigate the effects of corticosteroids on the healing of tracheal anastomoses. Forty-two adult female Wistar rats, randomly divided into five groups, underwent tracheal transection and primary anastomoses. The groups were assigned as follows: Group I, sham, ( N= 6); Group II, control, ( N= 6); Group III, dexamethasone, 0.1 mg kg −1per day, intramuscularly for a week ( N= 10); Group IV, dexamethasone, 1 mg kg −1per day, intramuscularly for a week ( N= 10); Group V, dexamethasone, 6 mg kg −1intramuscularly as a single dose ( N= 10). After 7 days, anastomotic healing was assessed by measurement of bursting pressure and hydroxyproline content. Histological examination was performed according to the modified Ehrlich/Hunt scale. The bursting pressure was significantly decreased in Group III and Group IV when compared to the control group ( P< 0.0001 for both groups). There was also significance between the bursting pressures of Group III and Group IV ( P< 0.01). However, the difference failed to reach significance between Group V and the control group. The reduction of bursting pressure was not reflected in diminished hydroxyproline content. The hydroxyproline content of the study groups (GIII, GIV and GV) were not statistically different compared with the control group. Except for inflammatory cell infiltration, histological parameters including epithelial regeneration, fibroblast proliferation, collagen content, and angiogenesis also demonstrated significant differences among the groups ( P< 0.05). The present study demonstrates that daily administration of dexamethasone for a week significantly impairs the healing of tracheal anastomoses in a dose-dependent manner while a single-dose postoperatively does not affect the healing process. |
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AbstractList | The deleterious effects of corticosteroids on anastomotic healing have been widely demonstrated in various tissues. This study is designed to investigate the effects of corticosteroids on the healing of tracheal anastomoses. Forty-two adult female Wistar rats, randomly divided into five groups, underwent tracheal transection and primary anastomoses. The groups were assigned as follows: Group I, sham, ( N= 6); Group II, control, ( N= 6); Group III, dexamethasone, 0.1 mg kg (-1) per day, intramuscularly for a week ( N= 10); Group IV, dexamethasone, 1 mg kg (-1) per day, intramuscularly for a week (N= 10); Group V, dexamethasone, 6 mg kg (-1) intramuscularly as a single dose ( N= 10). After 7 days, anastomotic healing was assessed by measurement of bursting pressure and hydroxyproline content. Histological examination was performed according to the modified Ehrlich/Hunt scale. The bursting pressure was significantly decreased in Group III and Group IV when compared to the control group (P< 0.0001 for both groups). There was also significance between the bursting pressures of Group III and Group IV (P< 0.01). However, the difference failed to reach significance between Group V and the control group. The reduction of bursting pressure was not reflected in diminished hydroxyproline content. The hydroxyproline content of the study groups (GIII, GIV and GV) were not statistically different compared with the control group. Except for inflammatory cell infiltration, histological parameters including epithelial regeneration, fibroblast proliferation, collagen content, and angiogenesis also demonstrated significant differences among the groups (P< 0.05). The present study demonstrates that daily administration of dexamethasone for a week significantly impairs the healing of tracheal anastomoses in a dose-dependent manner while a single-dose postoperatively does not affect the healing process. The deleterious effects of corticosteroids on anastomotic healing have been widely demonstrated in various tissues. This study is designed to investigate the effects of corticosteroids on the healing of tracheal anastomoses. Forty-two adult female Wistar rats, randomly divided into five groups, underwent tracheal transection and primary anastomoses. The groups were assigned as follows: Group I, sham, ( N= 6); Group II, control, ( N= 6); Group III, dexamethasone, 0.1 mg kg (-1) per day, intramuscularly for a week ( N= 10); Group IV, dexamethasone, 1 mg kg (-1) per day, intramuscularly for a week (N= 10); Group V, dexamethasone, 6 mg kg (-1) intramuscularly as a single dose ( N= 10). After 7 days, anastomotic healing was assessed by measurement of bursting pressure and hydroxyproline content. Histological examination was performed according to the modified Ehrlich/Hunt scale. The bursting pressure was significantly decreased in Group III and Group IV when compared to the control group (P< 0.0001 for both groups). There was also significance between the bursting pressures of Group III and Group IV (P< 0.01). However, the difference failed to reach significance between Group V and the control group. The reduction of bursting pressure was not reflected in diminished hydroxyproline content. The hydroxyproline content of the study groups (GIII, GIV and GV) were not statistically different compared with the control group. Except for inflammatory cell infiltration, histological parameters including epithelial regeneration, fibroblast proliferation, collagen content, and angiogenesis also demonstrated significant differences among the groups (P< 0.05). The present study demonstrates that daily administration of dexamethasone for a week significantly impairs the healing of tracheal anastomoses in a dose-dependent manner while a single-dose postoperatively does not affect the healing process. The deleterious effects of corticosteroids on anastomotic healing have been widely demonstrated in various tissues. This study is designed to investigate the effects of corticosteroids on the healing of tracheal anastomoses. Forty-two adult female Wistar rats, randomly divided into five groups, underwent tracheal transection and primary anastomoses. The groups were assigned as follows: Group I, sham, ( N= 6); Group II, control, ( N= 6); Group III, dexamethasone, 0.1 mg kg −1per day, intramuscularly for a week ( N= 10); Group IV, dexamethasone, 1 mg kg −1per day, intramuscularly for a week ( N= 10); Group V, dexamethasone, 6 mg kg −1intramuscularly as a single dose ( N= 10). After 7 days, anastomotic healing was assessed by measurement of bursting pressure and hydroxyproline content. Histological examination was performed according to the modified Ehrlich/Hunt scale. The bursting pressure was significantly decreased in Group III and Group IV when compared to the control group ( P< 0.0001 for both groups). There was also significance between the bursting pressures of Group III and Group IV ( P< 0.01). However, the difference failed to reach significance between Group V and the control group. The reduction of bursting pressure was not reflected in diminished hydroxyproline content. The hydroxyproline content of the study groups (GIII, GIV and GV) were not statistically different compared with the control group. Except for inflammatory cell infiltration, histological parameters including epithelial regeneration, fibroblast proliferation, collagen content, and angiogenesis also demonstrated significant differences among the groups ( P< 0.05). The present study demonstrates that daily administration of dexamethasone for a week significantly impairs the healing of tracheal anastomoses in a dose-dependent manner while a single-dose postoperatively does not affect the healing process. |
Author | Nayci, Ali Talas, Derya U Renda, Nurten Atis, Sibel Polat, Ayse Comelekoglu, Ulku Bagdatoglu, Celal |
Author_xml | – sequence: 1 givenname: Derya U surname: Talas fullname: Talas, Derya U organization: Department of Otolaryngology, Mersin University Medical Faculty, Mersin – sequence: 2 givenname: Ali surname: Nayci fullname: Nayci, Ali organization: Department of Pediatric Surgery, Mersin University Medical Faculty, Mersin – sequence: 3 givenname: Sibel surname: Atis fullname: Atis, Sibel organization: Department of Chest Diseases, Mersin University Medical Faculty, Mersin – sequence: 4 givenname: Ayse surname: Polat fullname: Polat, Ayse organization: Department of Pathology, Mersin University Medical Faculty, Mersin – sequence: 5 givenname: Ulku surname: Comelekoglu fullname: Comelekoglu, Ulku organization: Department of Biophysics, Mersin University Medical Faculty, Mersin – sequence: 6 givenname: Celal surname: Bagdatoglu fullname: Bagdatoglu, Celal organization: Department of Neurosurgery, Mersin University Medical Faculty, Mersin – sequence: 7 givenname: Nurten surname: Renda fullname: Renda, Nurten organization: Departments of Biochemistry, Hacettepe University Medical Faculty, Ankara, Turkey |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/12030793$$D View this record in MEDLINE/PubMed |
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Cites_doi | 10.1016/S0194-5998(00)70049-0 10.1006/cbir.1998.0302 10.1097/00003086-199611000-00032 10.1021/ac60205a053 10.1016/0006-291X(90)91583-E 10.1080/000164700317411951 10.1046/j.1524-475x.2001.00044.x 10.1097/00000658-197302000-00017 10.1097/00005537-200107000-00009 10.1001/archsurg.135.11.1265 10.1067/mhn.2000.109475 10.1002/hep.1840150226 10.1016/0008-8749(85)90011-5 10.1054/bjom.1999.0276 10.1016/0165-5876(95)01267-2 10.1016/0002-9610(86)90474-5 10.1016/S0039-6109(05)70566-1 10.1097/00006534-199905000-00021 10.1006/jsre.1997.5137 |
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Keywords | airway, anastomosis, corticosteroids, trachea, wound healing |
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Snippet | The deleterious effects of corticosteroids on anastomotic healing have been widely demonstrated in various tissues. This study is designed to investigate the... |
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SubjectTerms | Adrenal Cortex Hormones - therapeutic use airway, anastomosis, corticosteroids, trachea, wound healing Anastomosis, Surgical Animals Collagen - metabolism Coloring Agents Dose-Response Relationship, Drug Female Fibroblasts - pathology Hydroxyproline - metabolism Inflammation - pathology Neovascularization, Physiologic - drug effects Pressure Rats Rats, Wistar Regeneration - drug effects Trachea - injuries Trachea - pathology Wound Healing - drug effects |
Title | The effects of corticosteroids on the healing of tracheal anastomoses in a rat model |
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