Tetracycline nanoparticles loaded calcium sulfate composite beads for periodontal management

• Published in: Biochimica et biophysica acta Vol. 1840; no. 6; pp. 2080 - 2090
• Main Authors: Sindhura Reddy, N., Sowmya, S., Bumgardner, Joel D., Chennazhi, K.P., Biswas, Raja, Jayakumar, R.
• Format: Journal Article
• Language: English
• Published: Netherlands 01.06.2014
• Subjects: Adsorption; alkaline phosphatase; Anti-Bacterial Agents - administration & dosage; antibacterial properties; calcium sulfate; Calcium Sulfate - administration & dosage; cement; drug interactions; drugs; Escherichia coli; Fourier transform infrared spectroscopy; gelation; kinetics; microbial load; nanoparticles; Nanoparticles - administration & dosage; Periodontal Diseases - drug therapy; polymers; Porosity; scanning electron microscopy; Solubility; Staphylococcus aureus; tetracycline; Tetracycline - administration & dosage; Tetracycline - chemistry; tissue repair; X-ray diffraction; Periodontal regeneration; Antibacterial; Cytocompatible; Calcium sulfate; Tetracycline nanoparticles

The objective of this study was to fabricate, characterize and evaluate in vitro, an injectable calcium sulfate bone cement beads loaded with an antibiotic nanoformulation, capable of delivering antibiotic locally for the treatment of periodontal disease. Tetracycline nanoparticles (Tet NPs) were pr...