Does Parkinson's disease and type-2 diabetes mellitus present common pathophysiological mechanisms and treatments?

• Published in: CNS & neurological disorders drug targets Vol. 13; no. 3; p. 418
• Main Authors: Lima, Marcelo M S, Targa, Adriano D S, Noseda, Ana C D, Rodrigues, Lais S, Delattre, Ana Marcia, dos Santos, Fabiola V, Fortes, Mariana H, Maturana, Maira J, Ferraz, Anete C
• Format: Journal Article
• Language: English
• Published: United Arab Emirates 01.04.2014
• Subjects: Animals; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - epidemiology; Diabetes Mellitus, Type 2 - therapy; Disease Models, Animal; Dopamine - metabolism; Glucose - metabolism; Humans; Insulin - metabolism; Insulin Resistance - physiology; Parkinson Disease - complications; Parkinson Disease - epidemiology; Parkinson Disease - therapy

Parkinson's disease (PD) is the second most common neurodegenerative disease afflicting about 1% of people over 65 years old and 4-5% of people over 85 years. It is proposed that a cascade of deleterious factors is set in motion within that neuron made not of one, but rather of multiple factors...