Synthesis and characterization of curcumin loaded polymer/lipid based nanoparticles and evaluation of their antitumor effects on MCF-7 cells

• Published in: Biochimica et biophysica acta Vol. 1840; no. 6; pp. 1913 - 1922
• Main Authors: Kumar, Sathish Sundar Dhilip, Mahesh, Ayyavu, Mahadevan, Surianarayanan, Mandal, Asit Baran
• Format: Journal Article
• Language: English
• Published: Netherlands 01.06.2014
• Subjects: antineoplastic activity; Antineoplastic Agents - administration & dosage; apoptosis; Apoptosis - drug effects; atomic force microscopy; cell cycle; Cell Cycle - drug effects; curcumin; Curcumin - administration & dosage; Drug Delivery Systems; drugs; evaporation; flow cytometry; Fourier transform infrared spectroscopy; Humans; hydrophilicity; hydrophobicity; intravenous injection; MCF-7 Cells; nanocarriers; nanoparticles; Nanoparticles - administration & dosage; neoplasms; particle size; Polyhydroxyethyl Methacrylate - administration & dosage; polymers; scanning electron microscopy; Spectroscopy, Fourier Transform Infrared; stearic acid; Stearic Acids - administration & dosage; Thermogravimetry; X-Ray Diffraction; Polyhydroxyethyl methacrylate; Curcumin; Stearic acid; Polymeric lipid nanoparticle; Drug delivery system

Hybrid materials are synthesized using hydrophilic polymer and lipids which ensure their long term systemic circulation through intravenous administration and enhance loading of hydrophobic drugs. The purpose of this study is to prepare, characterize and evaluate the in vitro efficacy of curcumin lo...