Distinct MRI characteristics of spinal cord diffuse midline glioma, H3 K27-altered in comparison to spinal cord glioma without H3 K27-alteration and demyelination disorder
An applicable magnetic resonance imaging (MRI) biomarker for diffuse midline glioma (DMG), H3 K27-altered of the spinal cord is important for non-invasive diagnosis. To evaluate the efficacy of conventional MRI (cMRI) in distinguishing between DMGs, H3 K27-altered, gliomas without H3 K27-alteration,...
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Published in | Acta radiologica (1987) Vol. 65; no. 3; p. 284 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
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01.03.2024
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Abstract | An applicable magnetic resonance imaging (MRI) biomarker for diffuse midline glioma (DMG), H3 K27-altered of the spinal cord is important for non-invasive diagnosis.
To evaluate the efficacy of conventional MRI (cMRI) in distinguishing between DMGs, H3 K27-altered, gliomas without H3 K27-alteration, and demyelinating lesions in the spinal cord.
Between January 2017 and February 2023, patients with pathology-confirmed spinal cord gliomas (including ependymomas) with definite H3 K27 status and demyelinating diseases diagnosed by recognized criteria were recruited as the training set for this retrospective study. Morphologic parameter assessment was performed by two neuroradiologists on T1-weighted, T2-weighted, and contrast-enhanced T1-weighted imaging. Variables with high inter- and intra-observer agreement were included in univariable correlation analysis and multivariable logistic regression. The performance of the final model was verified by internal and external testing sets.
The training cohort included 21 patients with DMGs (13 men; mean age = 34.57 ± 13.489 years), 21 with wild-type gliomas (10 men; mean age = 46.76 ± 17.017 years), and 20 with demyelinating diseases (5 men; mean age = 49.50 ± 18.872 years). A significant difference was observed in MRI features, including cyst(s), hemorrhage, pial thickening with enhancement, and the maximum anteroposterior diameter of the spinal cord. The prediction model, integrating age, age
, and morphological characteristics, demonstrated good performance in the internal and external testing cohort (accuracy: 0.810 and 0.800, specificity: 0.810 and 0.720, sensitivity: 0.872 and 0.849, respectively).
Based on cMRI, we developed a model with good performance for differentiating among DMGs, H3 K27-altered, wild-type glioma, and demyelinating lesions in the spinal cord. |
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AbstractList | An applicable magnetic resonance imaging (MRI) biomarker for diffuse midline glioma (DMG), H3 K27-altered of the spinal cord is important for non-invasive diagnosis.
To evaluate the efficacy of conventional MRI (cMRI) in distinguishing between DMGs, H3 K27-altered, gliomas without H3 K27-alteration, and demyelinating lesions in the spinal cord.
Between January 2017 and February 2023, patients with pathology-confirmed spinal cord gliomas (including ependymomas) with definite H3 K27 status and demyelinating diseases diagnosed by recognized criteria were recruited as the training set for this retrospective study. Morphologic parameter assessment was performed by two neuroradiologists on T1-weighted, T2-weighted, and contrast-enhanced T1-weighted imaging. Variables with high inter- and intra-observer agreement were included in univariable correlation analysis and multivariable logistic regression. The performance of the final model was verified by internal and external testing sets.
The training cohort included 21 patients with DMGs (13 men; mean age = 34.57 ± 13.489 years), 21 with wild-type gliomas (10 men; mean age = 46.76 ± 17.017 years), and 20 with demyelinating diseases (5 men; mean age = 49.50 ± 18.872 years). A significant difference was observed in MRI features, including cyst(s), hemorrhage, pial thickening with enhancement, and the maximum anteroposterior diameter of the spinal cord. The prediction model, integrating age, age
, and morphological characteristics, demonstrated good performance in the internal and external testing cohort (accuracy: 0.810 and 0.800, specificity: 0.810 and 0.720, sensitivity: 0.872 and 0.849, respectively).
Based on cMRI, we developed a model with good performance for differentiating among DMGs, H3 K27-altered, wild-type glioma, and demyelinating lesions in the spinal cord. |
Author | Li, Xuanxuan Lu, Yiping Yin, Bo Ying, Yinwei Liu, Xiujuan Mei, Nan Ruan, Zhuoying |
Author_xml | – sequence: 1 givenname: Yinwei surname: Ying fullname: Ying, Yinwei organization: Department of Radiology, Huashan Hospital, Fudan University, Shanghai, PR China – sequence: 2 givenname: Xiujuan surname: Liu fullname: Liu, Xiujuan organization: Department of Pathology, Huashan Hospital, Fudan University, Shanghai, PR China – sequence: 3 givenname: Xuanxuan surname: Li fullname: Li, Xuanxuan organization: Department of Radiology, Huashan Hospital, Fudan University, Shanghai, PR China – sequence: 4 givenname: Nan surname: Mei fullname: Mei, Nan organization: Department of Radiology, Huashan Hospital, Fudan University, Shanghai, PR China – sequence: 5 givenname: Zhuoying surname: Ruan fullname: Ruan, Zhuoying organization: Department of Radiology, Huashan Hospital, Fudan University, Shanghai, PR China – sequence: 6 givenname: Yiping surname: Lu fullname: Lu, Yiping organization: Department of Radiology, Huashan Hospital, Fudan University, Shanghai, PR China – sequence: 7 givenname: Bo orcidid: 0000-0003-4134-8583 surname: Yin fullname: Yin, Bo organization: Department of Radiology, Huashan Hospital, Fudan University, Shanghai, PR China |
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Keywords | H3 K27-altered Spinal cord magnetic resonance imaging diffuse midline glioma demyelination |
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Snippet | An applicable magnetic resonance imaging (MRI) biomarker for diffuse midline glioma (DMG), H3 K27-altered of the spinal cord is important for non-invasive... |
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SubjectTerms | Adult Aged Brain Neoplasms - pathology Demyelinating Diseases - diagnostic imaging Glioma - diagnostic imaging Glioma - pathology Humans Magnetic Resonance Imaging - methods Male Middle Aged Retrospective Studies Spinal Cord - diagnostic imaging Young Adult |
Title | Distinct MRI characteristics of spinal cord diffuse midline glioma, H3 K27-altered in comparison to spinal cord glioma without H3 K27-alteration and demyelination disorder |
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