High Histamine Control Concentration Leads to False Negative Allergy Skin Testing

• Published in: American journal of rhinology & allergy Vol. 35; no. 6; p. 854
• Main Authors: Amirneni, Amulya, Tversky, Jody
• Format: Journal Article
• Language: English
• Published: United States 01.11.2021
• Subjects: Allergens; Histamine; Humans; Hypersensitivity - diagnosis; Reproducibility of Results; Skin Tests; nasal allergen challenge; allergen; histamine; cat; ragweed; sensitivity; skin test

Allergy skin test reliability depends on the reagents and controls selected. Histamine is used at 1 mg/ml and 6 mg/ml concentration but few studies address the rationale for selecting one versus the other and how this may impact diagnostic accuracy. To determine the rate of false negative allergen s...