Smooth Muscle Cell Transplantation into Myocardial Scar Tissue Improves Heart Function

• Published in: Journal of molecular and cellular cardiology Vol. 31; no. 3; pp. 513 - 522
• Main Authors: Li, Ren-Ke, Jia, Zhi-Qiang, Weisel, Richard D., Merante, Frank, Mickle, Donald A.G.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.03.1999
• Subjects: Angiogenesis; Animals; Blood Pressure; Cell transplantation; Cells, Cultured; Cicatrix - pathology; Cicatrix - surgery; Fetal Tissue Transplantation; Heart - physiopathology; Heart function; Male; Muscle, Smooth - cytology; Muscle, Smooth - embryology; Muscle, Smooth - transplantation; Myocardial Contraction; Myocardial Infarction - complications; Myocardial Infarction - pathology; Myocardial Infarction - physiopathology; Myocardial Infarction - surgery; Myocardial scar; Rats; Rats, Sprague-Dawley; Smooth muscle cells; Stomach - cytology; Angiogenesis; Myocardial scar; Heart function; Smooth muscle cells; Cell transplantation

This study was designed to evaluate the effect of smooth muscle cell transplantation into myocardial ventricular scar formed by cryo-necrosis. The left ventricular free wall (LVFW) of adult rats was cryo-necrosed. At 4 weeks after cryo-injury cultured fetal rat stomach smooth muscle cells (transplan...